Status and role of the ubiquitin–proteasome system in renal fibrosis
Biomedicine & Pharmacotherapy, 2024年07月25日
Abstract
The ubiquitin-proteasome system (UPS) is a basic regulatory mechanism in cells that essential for maintaining cell homeostasis, stimulating signal transduction, and determining fate. These biological processes require coordinated signaling cascades across members of the UPS to achieve substrate ubiquitination deubiquitination. role fibrotic diseases has attracted widespread attention, aberrant expression affects fibrosis process. In this review, we provide an overview its relevance diseases. Moreover, first time, explore detail how promotes or inhibits renal by regulating such as pathways, inflammation, oxidative stress, cycle, emphasizing status fibrosis. Further research on may reveal new strategies preventing